Mol* (/'molstar/) is a modern web-based open-source toolkit for visualisation and analysis of large-scale molecular data
 
Open Mol* Viewer Viewer Documentation Issues & Feedback
High-performance graphics and data handling of the Mol* Viewer allow users to simultaneously visualise up to hundreds of (superimposed) protein structures, play molecular dynamics trajectories, render cell-level models at atomic detail with tens of millions of atoms, or display huge models obtained by I/HM such as the Nuclear Pore Complex.

Interactive Examples

HIV in blood serum

CellPack model of enveloped HIV capsid with ~13M atoms.

Alpha orbitals and density of Atorvastatin

Alpha orbitals and density of Atorvastatin.

Zika+EM

Zika virus assembly and Cryo-EM density.

P-450 Superposition

Superposition and validation annotation of P-450 cytochromes.

GAIN domain

GAIN domain tethered agonist exposure (doi:10.1016/j.molcel.2020.12.042). Based on an animation by Ramon Guixà-González.

HIV in blood serum

CellPack model of enveloped HIV capsid in blood serum with 60+M atoms.

Nuclear Pore Complex

IH/M structure of the Nuclear Pore Complex.

Lighting

Render styles and lighting modes demonstration.

1RB8 Annotated Assembly

Annotated assembly of the phiX174 DNA binding protein (PDB id 1RB8).

Villin trajectory

Villin folding trajectory by Stefan Doerr (doi:10.6084/m9.figshare.12040257.v1).

SARS-CoV-2 Virion

SARS-CoV-2 Virion. Coarse-grained model by Alvin Yu et al. (doi:10.1016/j.bpj.2020.10.048).

BtuB molecules in a lipid bilayer

BtuB molecules in a lipid bilayer. Coarse-grained model by Matthieu Chavent et al. (doi:10.1038/s41467-018-05255-9).

bacterial flagellar motor-hook complex

Cryo-EM structure of the bacterial flagellar motor-hook complex (@Jiaxing_Tan_ et al. PDB 7CGO, doi:10.1016/j.cell.2021.03.057).

NAR Cover Image
Read about Mol* in Nucleic Acids Research
When using Mol*, please cite:
David Sehnal, Sebastian Bittrich, Mandar Deshpande, Radka Svobodová, Karel Berka, Václav Bazgier, Sameer Velankar, Stephen K Burley, Jaroslav Koča, Alexander S Rose: Mol* Viewer: modern web app for 3D visualization and analysis of large biomolecular structures, Nucleic Acids Research, 2021; 10.1093/nar/gkab31.
In memory of Jaroslav Koča.
Join Development on GitHub
The Mol* toolkit is a comprehensive solution for molecular data delivery, visualization and analysis that can be embedded into a wide range of 3rd party solutions. It includes a customizable plugin for high quality WebGL based molecular data visualization, as well as servers for model and experimental (X-ray, Cryo-EM, etc.) data delivery, efficient BinaryCIF data format support, and other exciting features.

Community Highlights

VSCoding-Sequence
VSCoding-Sequence is an extension for Visual Studio Code that allows for visualization of protein structures and molecular data in the editor.
PePr2Vis
PePr2Vis is a website for the calculation and visualization of protrusions on peripheral membrane proteins.
MolAR
MolAR makes chemical structures come to life with augmented reality, see them in a real-world environment.
Atomic Charge Calculator II and αCharges
Atomic Charge Calculator II and αCharges are web applications for fast computation of partial atomic charges visualized using a custom Mol* extension.
PDBe
PDBe
EMBL-EBI provides an open source integration of Mol* used by data resources such as PDBe, PDBe-KB and AlphaFold DB. This implementation can be embedded as a JS plugin or a Web Component with helper methods to facilitate programmatic interactions between the web application and the 3D viewer. Its features include a superposition view for overlaying all observed ligand molecules on representative protein conformations.
RCSB PDB provides an open source integration of Mol* that implements additional functionality, including presets for the visualization of structure alignments and structure motifs such as ligand binding sites, or the option to interactively add or hide chains and other structural components as showcased by the 3D Protein Feature View.
PDBe Superposition View
RCSB 3D Protein Feature View

Extensions

MolViewSpec
Volumes and Segmentations
MolViewSpec Extension
Volumes and Segmentations Extension
MolViewSpec provides a generic mechanism for describing visual scenes or views that are used in molecular visualizations. It adopts declarative data-driven approach to describe, load, render, and visually deliver molecular structures, along with 3D representations, coloring schemes, and associated structural, biological, or functional annotations.
Volumes and Segmentations extension adds support for large scale volumetric data & their segmentations. Building on the existing Mol* ecosystem, this extension allows seamless integration of biomolecular data from cellular to atomic scale. It provides the means to visualize large-scale volumetric and segmentation data from cryo-EM, light miscroscopy, volume-EM, and other imagining experiments together with related 3D model data and biological annotations.
The project is an open collaboration started by
PDBe RCSB CEITEC
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